Cockroach diuretic hormones: Characterization of a calcitonin-like peptide in insects
AUTOR(ES)
Furuya, Kenji
FONTE
National Academy of Sciences
RESUMO
Insect diuretic hormones are crucial for control of water balance. We isolated from the cockroach Diploptera punctata two diuretic hormones (DH), Dippu-DH31 and Dippu-DH46, which increase cAMP production and fluid secretion in Malpighian tubules of several insect species. Dippu-DH31 and -DH46 contain 31 and 46 amino acids, respectively. Dippu-DH46 belongs to the corticotropin-releasing factor (CRF)-like insect DH family, whereas Dippu-DH31 has little sequence similarity to the CRF-like DH, but is similar to the calcitonin family. Dippu-DH46 and -DH31 have synergistic effects in D. punctata but have only additive effects in Locusta migratoria. Dippu-DH31 represents a distinct type of insect DH with actions that differ from those of previously identified insect peptides with diuretic activity.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=18626Documentos Relacionados
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