Coexpression of keratin- and vimentin-type intermediate filaments in human metastatic carcinoma cells.
AUTOR(ES)
Ramaekers, F C
RESUMO
Metastatic tumor cells of epithelial origin present in effusions from human serous cavity fluids (ascites or pleural fluid) were examined for their intermediate-sized filament types by using antibodies to keratin, vimentin, and desmin in the indirect immunofluorescence technique. Solid epithelial tumors (both primary carcinomas and their metastases) contain keratin intermediate-sized filaments exclusively. However, when these cells are present in ascitic or pleural fluid, they also express vimentin, which occurs in a fibrillar organization. The possible effects of this additional, but temporary, cytoskeleton on metastatic growth or aggressiveness (or both) are discussed.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=393878Documentos Relacionados
- Fc-mediated binding of IgG to vimentin-type intermediate filaments in vascular endothelial cells.
- Intermediate Filaments in Motion: Observations of Intermediate Filaments in Cells Using Green Fluorescent Protein-VimentinV⃞
- Intermediate filaments in synovial lining cells in rheumatoid arthritis and other arthritides are of vimentin type.
- Inhibition of vimentin synthesis and disruption of intermediate filaments in simian virus 40-infected monkey kidney cells.
- Phosphorylation and disassembly of intermediate filaments in mitotic cells.