Collagen matrices behavior in treatment of skin rat wounds / Comportamento de matrizes de colágeno utilizadas no tratamento de feridas planas induzidas em pele de rato
AUTOR(ES)
Raquel Cecília Goy Girardi
DATA DE PUBLICAÇÃO
2005
RESUMO
The potentiality of the use of a collagen based matrix and of a cream prepared by the mixture of a commercial cream plus collagen (90:10 w/w) were evaluated in the healing process of rats skin. The acellular collagen matrix and the collagen gel were obtained by an alkaline treatment of porcine serosa which does not damage the native collagen structure and removes cellular components. This study compared by macroscopy analysis and histology the skin healing repair of wounds treated with physiological solution or commercial cream (control groups) and those treated with collagen based matrix suture or commercial cream plus collagen mix. The wounds were made by removing a skin flap with 20 MM POT.2 and have received treatment every day. The material for histology was retired on the 3rd, 5th, 7th and 9th days after surgery. Even without an accentuated difference in the healing process of both control groups and the wounds treated with the commercial cream plus collagen, its presence in the cream showed a small difference of the collagen level in the new skin what validate more investigations on this way, searching better cream:gel proportion and/or different gel concentration. The matrix demonstrated to be a very good option to help wound healing because it is easily shelf able and obtainable, it has cheap cost and it is extremely nice to handle (resistant and manipulation able), besides to follow the main requirements present in the literature citation for any biologic occlusive dressing
ASSUNTO(S)
pele porcine serosa skin colágeno cicatrização wound healing collagen serosa porcina
Documentos Relacionados
- "Pele porcina como fonte de matrizes tridimensionais de colágeno"
- Aplicabilidade de uma película de celulose cristalina no tratamento de feridas cutâneas induzidas em ratos wistar
- Matrizes de colágeno para liberação controlada de progesterona
- Mineralização in vitro de matrizes de colágeno aniônico derivadas de tecidos biológicos
- Associação fitoterápica no tratamento de feridas cutâneas induzidas em equinos