Common DNA structural features exhibited by eukaryotic ribosomal gene promoters.
AUTOR(ES)
Marilley, M
RESUMO
Nucleotide sequences of DNA regions containing eukaryotic ribosomal promoters were analysed using strategies designed to reveal sequence-directed structural features. DNA curvature, duplex stability and pattern of twist angle variation were studied by computer modelling. Although ribosomal promoters are known to lack sequence homology (unless very closely related species are considered), investigation of these structural characteristics uncovered striking homologies in all the taxonomic groups examined so far. This wide conservation of DNA structures, while DNA sequence is not conserved, suggests that the determined structures are fundamental for ribosomal promoter function. Moreover, this result agrees well with the recent observations showing that RNA polymerase I transcription factors have not evolved as intensively as previously suspected.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=145945Documentos Relacionados
- Tetracycline-reversible silencing of eukaryotic promoters.
- Structural basis of protein kinase C activation by tumor promoters.
- Conserved features of coordinately regulated E. coli promoters.
- Common features in DNA recognition helices of eukaryotic transcription factors.
- Corrigendum: Common features in DNA recognition helices of eukaryotic transcription factors