Comparative in vitro antimicrobial activity of carumonam, a new monocyclic beta-lactam.
AUTOR(ES)
Smith, B R
RESUMO
The antimicrobial activity of carumonam (formerly RO-17-2301), a monocyclic beta-lactam antibiotic, was compared with those of aztreonam, cefotaxime, cefoperazone, ceftazidime, piperacillin, and gentamicin against 455 bacterial isolates. Carumonam did not possess activity against gram-positive cocci and was generally comparable to aztreonam and ceftazidime for most gram-negative bacilli. However, carumonam was the most active beta-lactam against gentamicin-resistant Pseudomonas aeruginosa strains (90% MIC, 8 micrograms/ml).
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=176408Documentos Relacionados
- Antibacterial activity of RU44790, a new N-tetrazolyl monocyclic beta-lactam.
- In vitro and in vivo antibacterial activities of carumonam (AMA-1080), a new N-sulfonated monocyclic beta-lactam antibiotic.
- Disposition of carumonam (AMA-1080/Ro 17-2301), a new N-sulfonated monocyclic beta-lactam, in rats and dogs.
- Comparative In Vitro Activity of New Beta-Lactam Antibiotics Against Anaerobic Bacteria
- Comparative in-vitro activity of selected new beta-lactam antimicrobials against Neisseria gonorrhoeae.