Comparative pathogenicity of four strains of Aleutian disease virus for pastel and sapphire mink.
AUTOR(ES)
Hadlow, W J
RESUMO
Information was sought on the comparative pathogenicity of four North American strains (isolates) of Aleutian disease virus for royal pastel (a non-Aleutian genotype) and sapphire (an Aleutian genotype) mink. The four strains (Utah-1, Ontario [Canada], Montana, and Pullman [Washington]), all of mink origin, were inoculated intraperitoneally and intranasally in serial 10-fold dilutions. As indicated by the appearance of specific antibody (counterimmunoelectrophoresis test), all strains readily infected both color phases of mink, and all strains were equally pathogenic for sapphire mink. Not all strains, however, regularly caused Aleutian disease in pastel mink. Infection of pastel mink with the Utah-1 strain invariably led to fatal disease. Infection with the Ontario strain caused fatal disease nearly as often. The Pullman strain, by contrast, almost never caused disease in infected pastel mink. The pathogenicity of the Montana strain for this color phase was between these extremes. These findings emphasize the need to distinguish between infection and disease when mink are exposed to Aleutian disease virus. The distinction has important implications for understanding the natural history of Aleutian disease virus infection in ranch mink.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=264602Documentos Relacionados
- Temporal replication of the Pullman strain of Aleutian disease virus in royal pastel mink.
- Antibody-Forming Cells and Serum Hemolysin Responses of Pastel and Sapphire Mink Inoculated with Aleutian Disease Virus
- Interferon response in normal and Aleutian disease virus-infected mink.
- Analysis of Aleutian disease virus infection in vitro and in vivo: demonstration of Aleutian disease virus DNA in tissues of infected mink.
- Identification of Aleutian mink disease parvovirus transcripts in macrophages of infected adult mink.