Comparative Pharmacokinetics of Cephalexin, Cefaclor, Cefadroxil, and CGP 9000
AUTOR(ES)
Lode, Hartmut
RESUMO
In a randomized crossover study, the pharmacokinetics of three new cephalosporin antibiotics, cefaclor, cefadroxil, and CGP 9000, in comparison to cephalexin, were determined after oral administration, by capsules, of 1,000 mg on an empty stomach in 12 normal subjects. Serum concentrations were measured during a period of 8 h, and urine recovery was measured during 24 h. The significant parameters of bioavailability of an orally administered substance were determined. The maximal serum concentrations (ymax) for cephalexin, cefaclor, cefadroxil, and CGP 9000 (in milligrams per liter) were: 38.8 ± 8.1; 34.6 ± 7.8; 33.0 ± 5.4; and 23.3 ± 7.3, respectively. The areas under the curve (in hours × milligrams per liter) were: 93.0 ± 14.8; 74.5 ± 9.9; 70.1 ± 9.0; and 108.5 ± 18.4, respectively. In a further crossover study with six subjects, 1,000 mg of cephalexin and of cefadroxil were given during a standard breakfast. The ymax of cephalexin decreased to 23.1 ± 6.6 mg/liter, in contrast to cefadroxil, with an unchanged ymax of 32.7 ± 3.4 mg/liter.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=352777Documentos Relacionados
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