Comparison of antiviral activities of cloned and native human interferons against herpes simplex virus types 1 and 2 and human cytomegalovirus.
AUTOR(ES)
Rasmussen, L E
RESUMO
Five recombinant alpha interferons and two recombinant beta interferons have been tested for their ability to inhibit yields of herpes simplex virus types 1 and 2 and human cytomegalovirus in human embryonic lung cells. All of the alpha species and both of the beta forms (cysteine and serine) were active against the herpesviruses tested in this study. Neither the recombinant alpha nor the recombinant beta interferons exceeded the activity of the native species against herpes simplex viruses types 1 and 2. However, the recombinant beta interferons inhibited cytomegalovirus more than either the native beta or the alpha interferon species with the exception of interferon alpha K (alpha 6).
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=179974Documentos Relacionados
- Antigenic cross-reactions among herpes simplex virus types 1 and 2, Epstein-Barr virus, and cytomegalovirus.
- In vitro activities of penciclovir and acyclovir against herpes simplex virus types 1 and 2.
- Biological Characteristics of Cloned Populations of Herpes Simplex Virus Types 1 and 2
- Reactivation of herpes simplex virus type 2 from a quiescent state by human cytomegalovirus.
- Effect of cloned human interferons on protein synthesis and morphogenesis of herpes simplex virus.