Comparison of bioactive compounds content in leaf extracts of Passiflora incarnata, P. caerulea and P. alata and in vitro cytotoxic potential on leukemia cell lines
AUTOR(ES)
Ozarowski, Marcin, Piasecka, Anna, Paszel-Jaworska, Anna, Chaves, Douglas Siqueira de A., Romaniuk, Aleksandra, Rybczynska, Maria, Gryszczynska, Agnieszka, Sawikowska, Aneta, Kachlicki, Piotr, Mikolajczak, Przemyslaw L., Seremak-Mrozikiewicz, Agnieszka, Klejewski, Andrzej, Thiem, Barbara
FONTE
Rev. bras. farmacogn.
DATA DE PUBLICAÇÃO
2018-04
RESUMO
ABSTRACT Passiflora caerulea L., P. alata Curtis and P. incarnata L. (synonym for P. edulis Sims), are the most popular representatives of the Passiflora genus in South America. In recent years, a growing attention is paid to the biological activity and phytochemical profiles of crude extracts from various species of Passiflora in worldwide. The aim of this study was to evaluate and to compare of anti-leukemic activity of the dry crude extracts from leaves of three Passiflora species from greenhouse of Poland in two human acute lymphoblastic leukemia cell lines: CCRF-CEM and its multidrug resistant variant. Two systems of liquid chromatography in order to assessment of phytochemical composition of extracts were applied. Extracts of P. alata and P. incarnata showed the potent inhibitory activity against human acute lymphoblastic leukemia CCRF-CEM, while P. caerulea not showed activity (or activity was poor). Despite similarities in quality phytochemical profile of extracts from P. caerulea and P. incarnata, differences in quantity of chemical compounds may determine their various pharmacological potency. For the activity of P. alata extract the highest content of terpenoids and a lack of flavones C-glycosides are believed to be crucial. Summarizing, the crude extract from P. alata leaves may be considered as a substance for complementary therapy for cancer patients.
Documentos Relacionados
- Applying design of experiments (DOE) to flavonoid extraction from Passiflora alata and P. edulis
- Co-extracted bioactive compounds in Capsicum fruit extracts prevent the cytotoxic effects of capsaicin on B104 neuroblastoma cells
- Volatile compounds of Nectandra salicina (lauraceae) from Costa Rica and their cytotoxic activity on cell lines
- Estudo de algumas variáveis que interferem na concentração de flavonóides do cultivo de folhas de de Passiflora incarnata L.
- The combination of Passiflora alata and Valeriana officinalis on memory tasks in mice: comparison with diazepam