Comparison of the Heme Iron Utilization Systems of Pathogenic Vibrios
AUTOR(ES)
O’Malley, S. M.
FONTE
American Society for Microbiology
RESUMO
Vibrio alginolyticus, Vibrio fluvialis, and Vibrio parahaemolyticus utilized heme and hemoglobin as iron sources and contained chromosomal DNA similar to several Vibrio cholerae heme iron utilization genes. A V. parahaemolyticus gene that performed the function of V. cholerae hutA was isolated. A portion of the tonB1 locus of V. parahaemolyticus was sequenced and found to encode proteins similar in amino acid sequence to V. cholerae HutW, TonB1, and ExbB1. A recombinant plasmid containing the V. cholerae tonB1 and exbB1D1 genes complemented a V. alginolyticus heme utilization mutant. These data suggest that the heme iron utilization systems of the pathogenic vibrios tested, particularly V. parahaemolyticus and V. alginolyticus, are similar at the DNA level, the functional level, and, in the case of V. parahaemolyticus, the amino acid sequence or protein level to that of V. cholerae.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=93831Documentos Relacionados
- Characterization of the Plesiomonas shigelloides Genes Encoding the Heme Iron Utilization System
- The Bordetella bhu Locus Is Required for Heme Iron Utilization
- Effects of serum carrier proteins on the growth of pathogenic neisseriae with heme-bound iron.
- Yersinia pestis TonB: Role in Iron, Heme, and Hemoprotein Utilization
- Iron-regulated hemolysin production and utilization of heme and hemoglobin by Vibrio cholerae.