Comparison of the in vitro transforming activities of human papillomavirus types.

AUTOR(ES)

Storey, A

RESUMO

The association of certain human papillomavirus (HPV) types with the majority of human cervical carcinomas suggests a role for the virus in the development of this type of cancer. In this paper, we have examined the transforming properties of several HPV types where the early region genes of the virus are under the control of a strong heterologous promoter and show that major differences exist between the HPV types in their ability to transform primary rat kidney epithelial cells in conjunction with an activated ras oncogene. Those HPV types most commonly found in carcinomas--types 16, 18, 31 and 33--are capable of co-operating with ras to transform primary cells, but those types most commonly found in benign lesions--types 6 and 11--are not. We further demonstrate that the E7 gene of HPV16 by itself is sufficient to co-operate with activated ras to produce transformed cells which are tumorigenic in immunocompetent animals.

Documentos Relacionados

• Different polypeptide composition of two human rotavirus types.
• Human papillomavirus type 29 (HPV-29), an HPV type cross-hybridizing with HPV-2 and with HPV-3-related types.
• Clinical presentations of vascular malformations of the brain stem: comparison of angiographically positive and negative types.
• Arabic reading types.
• Mesenchyme-epithelial interactions in human endometrium. Prostaglandin synthesis in separated cell types.