Comparison of ZFY and ZFX gene structure and analysis of alternative 3' untranslated regions of ZFY.
AUTOR(ES)
North, M
RESUMO
We have cloned and sequenced transcripts from the X- and Y-linked zinc-finger genes ZFX and ZFY respectively and discuss a possible mechanism of post-transcriptional control by which these genes can be widely expressed but translated in only specific tissues. We report the identification of a novel 3'UTR (untranslated region) present in ZFY which is highly conserved among primates and contains a series of motifs implicated as mRNA instability determinants. These sequences can be substantially removed by polyadenylation directed from consensus (AATAAA) and non-consensus (AATATAAA) sequences in adult testis. The DNA-binding domains of the ZFY and ZFX proteins are compared using present models for zinc-finger/DNA interactions. Additionally, the genomic organisation of the ZFY coding sequence is presented as compared to that of ZFX.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=328173Documentos Relacionados
- Comparison of human ZFY and ZFX transcripts.
- 5' and 3' untranslated regions of pestivirus genome: primary and secondary structure analyses.
- Control of Glutamate Receptor 2 (GluR2) Translational Initiation by Its Alternative 3′ Untranslated Regions
- Structure of the constant and 3' untranslated regions of the murine Balb/c gamma 2a heavy chain messenger RNA.
- Expression of human alpha-tubulin genes: interspecies conservation of 3' untranslated regions.
