Congo red inhibition of scrapie agent replication.
AUTOR(ES)
Caughey, B
RESUMO
Congo red inhibits the accumulation of protease-resistant PrP in scrapie-infected mouse neuroblastoma cells. Here we show that Congo red also inhibits the replication of scrapie infectivity in these cells. This observation is consistent with the idea that protease-resistant PrP is a vital component of the scrapie agent or that agent replication depends on the presence of protease-resistant PrP in the cell.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=238051Documentos Relacionados
- Congo red prolongs the incubation period in scrapie-infected hamsters.
- Replication of the scrapie agent in ocular neural tissues.
- Immune system-dependent and -independent replication of the scrapie agent.
- Phosphonoformate inhibition of visna virus replication.
- Inhibition of cell-cell interactions in Myxococcus xanthus by congo red.
