CONJUGAL FERTILITY ASSOCIATED WITH RESISTANCE FACTOR R IN ESCHERICHIA COLI

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Sugino, Yoshinobu (Osaka University, Osaka, Japan) and Yukinori Hirota. Conjugal fertility associated with resistance factor R in Escherichia coli. J. Bacteriol. 84:902–910. 1962.—The introduction of the contagious drug-resistance factor, R, into an F− strain of Escherichia coli allows the R+F− strain to mate with F−R− strains. The chromosome fragment transferred from the R+ cell is relatively large, comparable to the conjugation between F+ or Hfr male and F− female bacteria. The complex R factor has been analyzed by transduction with phage Pl. Within the R factor, the fertility determinant is inseparable from the determinant responsible for its infectivity, but can be separated from the loci for drug resistance. R thus resembles the category of complex F factors (F-primes) previously analyzed.

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