Contrasting Roles of Mannan-Specific Monoclonal Immunoglobulin M Antibodies in the Activation of Classical and Alternative Pathways by Candida albicans
AUTOR(ES)
Zhang, Mason X.
FONTE
American Society for Microbiology
RESUMO
Polyclonal antimannan immunoglobulin G (IgG) activates the classical complement pathway and accelerates initiation of the alternative pathway by Canidida albicans. This dual role was assessed for two antimannan IgM monoclonal antibodies (MAbs). MAb B6.1 is specific for an epitope on the acid-labile portion of C. albicans phosphomannan; MAb B6 is specific for an epitope on the acid-stable region. Both MAbs were potent activators of the classical pathway but poor facilitators of alternative pathway initiation.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=108767Documentos Relacionados
- Mannan-specific immunoglobulin G antibodies in normal human serum mediate classical pathway initiation of C3 binding to Candida albicans.
- Mannan-Specific Immunoglobulin G Antibodies in Normal Human Serum Accelerate Binding of C3 to Candida albicans via the Alternative Complement Pathway
- Characterization of Candida albicans mannan-induced, mannan-specific delayed hypersensitivity suppressor cells.
- Mannan as an antigen in cell-mediated immunity (CMI) assays and as a modulator of mannan-specific CMI.
- Distinct characteristics of initiation of the classical and alternative complement pathways by Candida albicans.