Convergence of two repressors through heterodimer formation of androgen receptor and testicular orphan receptor-4: A unique signaling pathway in the steroid receptor superfamily
AUTOR(ES)
Lee, Yi-Fen
FONTE
The National Academy of Sciences
RESUMO
The androgen receptor (AR) binds to androgen response elements and regulates target genes via a mechanism involving coregulators. Here we demonstrate that the AR can interact with the testicular orphan receptor-4 (TR4) and function as a repressor to down-regulate the TR4 target genes by preventing the TR4 binding to its target DNA. Interestingly, the heterodimerization of AR and TR4 also allows TR4 to repress AR target gene expression. Simultaneous exposure to both receptors therefore could result in bidirectional suppression of their target genes. Together, these data demonstrate that the coupling of two different receptors, through the heterodimerization of AR and TR4, is a unique signaling pathway in the steroid receptor superfamily, which may facilitate further understanding of the complicated androgen action in prostate cancer or libido.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=24715Documentos Relacionados
- Human and rat TR4 orphan receptors specify a subclass of the steroid receptor superfamily.
- COUP-TF gene: a structure unique for the steroid/thyroid receptor superfamily.
- Growth retardation and abnormal maternal behavior in mice lacking testicular orphan nuclear receptor 4
- Testosterone Signaling through Internalizable Surface Receptors in Androgen Receptor-free Macrophages
- Regulation of the Nur77 orphan steroid receptor in activation-induced apoptosis.