Convergent Evolution of Chromosomal Sex-Determining Regions in the Animal and Fungal Kingdoms
AUTOR(ES)
Fraser, James A
FONTE
Public Library of Science
RESUMO
Sexual identity is governed by sex chromosomes in plants and animals, and by mating type (MAT) loci in fungi. Comparative analysis of the MAT locus from a species cluster of the human fungal pathogen Cryptococcus revealed sequential evolutionary events that fashioned this large, highly unusual region. We hypothesize that MAT evolved via four main steps, beginning with acquisition of genes into two unlinked sex-determining regions, forming independent gene clusters that then fused via chromosomal translocation. A transitional tripolar intermediate state then converted to a bipolar system via gene conversion or recombination between the linked and unlinked sex-determining regions. MAT was subsequently subjected to intra- and interallelic gene conversion and inversions that suppress recombination. These events resemble those that shaped mammalian sex chromosomes, illustrating convergent evolution in sex-determining structures in the animal and fungal kingdoms.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=526376Documentos Relacionados
- Interspecies Comparison Reveals Evolution of Control Regions in the Nematode Sex-Determining Gene Tra-2
- The Sex-Determining Mechanism of Drosophila Miranda
- Genetic Interactions among Sex-Determining Genes in the Fern Ceratopteris Richardii
- Molecular Cloning and Duplication of the Nematode Sex-Determining Gene Tra-1
- Signatures of selection among sex-determining alleles of the honey bee