Coproporphyrin I and III excretion in bile and urine
AUTOR(ES)
Kaplowitz, Neil
RESUMO
The excretion of coproporphyrin isomers I and III was studied in the rat. Both isomers were found to bind equally to rat plasma and liver cytosol in vitro and to disappear from plasma at equal rates after single injections in vivo. During equimolar infusions of isomers into bile fistula animals, both the I and III isomers were excreted in bile in a concentration ratio of 2:1, respectively. Pretreatment of animals with ethinylestradiol or simultaneous infusions of phenoldibromophthalein disulfonate caused a reduction in total hepatic excretion with no change in the 2:1 ratio in bile. As hepatic excretion fell, excretion of both isomers in urine rose, with an increase in the proportion of the I isomer. The findings mimic those reported to occur in man and can be explained by inhibition of a common carrier which requires a stereospecific configuration that statistically favors the hepatic transport of the symmetrical coproporphyrin I isomer.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=292439Documentos Relacionados
- STUDIES OF COPROPORPHYRIN. I. THE PER DIEM EXCRETION AND ISOMER DISTRIBUTION OF COPROPORPHYRIN IN NORMAL HUMAN URINE 1
- Excretion of Urinary Coproporphyrin in Lead Poisoning. Part 1 and 2: Part I: Level of the Precursor of Coproporphyrin and Preformed Coproporphyrin in Fresh Urine
- THE EXCRETION OF COPROPORPHYRIN I FOLLOWING HEMORRHAGE IN DOGS
- Urinary Coproporphyrin Isomers I and III in Lead Workers and a Control Group
- STUDIES OF COPROPORPHYRIN. IV. THE PER DIEM EXCRETION AND ISOMER DISTRIBUTION IN THE URINE IN INFECTIOUS HEPATITIS, INFECTIOUS MONONUCLEOSIS, AND MECHANICAL JAUNDICE 1