Correction of Cellular Metachromasia in Cultured Fibroblasts in Several Inherited Mucopolysaccharidoses*
AUTOR(ES)
Danes, B. Shannon
RESUMO
Cultured fibroblasts from the genetic mucopolysaccharidoses store higher than normal amounts of the polyanionic glycosaminoglycans (mucopolysaccharides); histochemical staining with the cationic dyes toluidine blue O and Alcian blue detects such intracellular accumulation. With these stains as phenotypic markers, correction of the cellular abnormality by fibroblasts derived from different patients and their heterozygous parents has been observed among several genetic types of mucopolysaccharidoses. In this way, syndromes previously considered clinically homogeneous have been separated into distinct groups.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=283213Documentos Relacionados
- Letter: Cellular metachromasia with toluidine blue O in cultured white cells of cystic fibrosis heterozygotes.
- Defective organization of actin in cultured skin fibroblasts from patients with inherited adenocarcinoma
- Immunochemical studies on cultured fibroblasts from patients with inherited methylmalonic acidemia.
- Human milk stimulates DNA synthesis and cellular proliferation in cultured fibroblasts.
- Simulation of Genetic Mucopolysaccharidoses in Normal Human Fibroblasts by Alteration of pH of the Medium