Crystallization of a common cold virus, human rhinovirus 14: “Isomorphism” with poliovirus crystals

AUTOR(ES)

Erickson, John W.

RESUMO

Crystals of rhinovirus 14 have been grown reproducibly. They diffract x-rays to a resolution of at least 3.5 Å. The orthorhombic crystal unit cell contains two virions, each situated on a crystallographic twofold axis. At less than 30-Å resolution, the space group approximates to 1222 with the particles possessing 222 pseudo crystallographic symmetry. The crystals are “isomorphous” with type I polio crystals [Finch, J. T. & Klug, A. (1959) Nature (London) 183, 1709-1714; Hogle, J. M. (1982) J. Mol. Biol. 160, 663-668], suggesting some similarities of structure between enteroviruses and rhinoviruses.

Documentos Relacionados

• The complete nucleotide sequence of a common cold virus: human rhinovirus 14.
• A common cold virus, rhinovirus 16, potentiates airway inflammation after segmental antigen bronchoprovocation in allergic subjects.
• Acid-induced structural changes in human rhinovirus 14: possible role in uncoating.
• Use of monoclonal antibodies to identify four neutralization immunogens on a common cold picornavirus, human rhinovirus 14.
• Similar Interactions of the Poliovirus and Rhinovirus 3D Polymerases with the 3′ Untranslated Region of Rhinovirus 14