Cycloheximide and Acetoxycycloheximide: Inhibition of Tyrosine Hydroxylase Activity and Amnestic Effects

AUTOR(ES)

Flexner, Louis B.

RESUMO

Mice and rats trained after treatment with cycloheximide or acetoxycycloheximide in a conditioned avoidance response develop an amnesia of their training experience. This amnesia has been attributed to the profound inhibition of protein synthesis caused by the two antibiotics. Evidence is presented that additionally the antibiotics inhibit the activity of tyrosine hydroxylase, a finding that suggests that their amnestic effect may be due in part to reduction of the functional pool of norepinephrine.

Documentos Relacionados

• Tyrosine hydroxylase in human adrenal and pheochromocytoma: localization, kinetics, and catecholamine inhibition
• Electrical stimulation of preganglionic nerve increases tyrosine hydroxylase activity in sympathetic ganglia.
• Coexistence and gene expression of phenylethanolamine N-methyltransferase, tyrosine hydroxylase, and neuropeptide tyrosine in the rat and bovine adrenal gland: effects of reserpine.
• INCREASE IN RAT BRAIN TYROSINE HYDROXYLASE ACTIVITY PRODUCED BY ELECTROCONVULSIVE SHOCK*
• Tyrosine hydroxylase and levodopa responsive dystonia.