Cytokines as adjuvants for vaccines: antigen-specific responses differ from polyclonal responses.

AUTOR(ES)

Taylor, C E

RESUMO

The use of cytokines in the administration of vaccines has a unique value in obtaining the appropriate immune response and in ensuring a protective outcome. Earlier studies indicating that cytokines can influence the generation of a particular antibody isotype may represent an oversimplification of a more complex problem. Several studies discussed in this review show that the effect of a given cytokine on the immune response depends on whether one examines the antigen-specific response or the polyclonal response (i.e., total serum immunoglobulins). Further, a balanced regulation of immune responsiveness is important in maintaining homeostasis of the immune system. Consequently, for any vaccine that uses cytokines to boost the response, due consideration must be given to these important variables.

Documentos Relacionados

• Encapsulation of Cryptococcus neoformans impairs antigen-specific T-cell responses.
• Human infection with Trypanosoma cruzi induces parasite antigen-specific cytotoxic T lymphocyte responses.
• Lipopolysaccharide from Brucella abortus behaves as a T-cell-independent type 1 carrier in murine antigen-specific antibody responses.
• Messenger RNA for an antigen-specific binding molecule from an antigen-specific T-cell hybrid.
• Modulation of Antigen-Specific Humoral Responses in Rhesus Macaques by Using Cytokine cDNAs as DNA Vaccine Adjuvants