Cytoplasmic distinction of avirulent and virulent Rickettsia prowazekii: fusion of infected fibroblasts with macrophage-like cells.
AUTOR(ES)
Winkler, H H
RESUMO
L-929 cells with virulent or avirulent Rickettsia prowazekii growing in their cytoplasm were fused with cells of the macrophage-like cell line RAW264.7. Fusion occurred between the two cell types, producing heterokaryons containing R. prowazekii. Both the number of rickettsiae per infected heterokaryon and the percentage of heterokaryons infected with rickettsiae decreased in experiments with the avirulent strain compared to those with the virulent strain. These results indicate that the differential survival of the virulent strain in macrophages is some unknown function of the cytoplasm of the macrophage and that the distinction is not only at the phagolysosome level.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=348187Documentos Relacionados
- Differentiation Between Virulent and Avirulent Strains of Rickettsia prowazekii by Macrophage-Like Cell Lines
- Effect of mouse lymphokines and cloned mouse interferon-gamma on the interaction of Rickettsia prowazekii with mouse macrophage-like RAW264.7 cells.
- Biochemical and physiological changes induced by anthrax lethal toxin in J774 macrophage-like cells.
- Lysosomal response of a murine macrophage-like cell line persistently infected with Coxiella burnetii.
- Cryptococcus neoformans fails to induce nitric oxide synthase in primed murine macrophage-like cells.
