Demonstration of antigenic variation among rabies virus isolates by using monoclonal antibodies to nucleocapsid proteins.
AUTOR(ES)
Smith, J S
RESUMO
Rabies virus isolates from terrestrial animals in six areas of the United States were examined with a panel of monoclonal antibodies to nucleocapsid proteins. Characteristic differences in immunofluorescence reactions permitted the formation of four antigenically distinct reaction groups from the 231 isolates tested. The geographic distribution of these groups corresponded well with separate rabies enzootic areas recognized by surveillance of sylvatic rabies in the United States. Distinctive reaction patterns were also identified for viral proteins from four infected bat species, and identical patterns were found in eight isolated cases of rabies in terrestrial animals. These findings suggest that monoclonal antibodies can be used to study the prevalence, distribution, and transmission of rabies among wildlife species.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=268974Documentos Relacionados
- Antigenic differences among isolates of Plasmodium falciparum demonstrated by monoclonal antibodies.
- Quantification of human cytomegalovirus viremia by using monoclonal antibodies to different viral proteins.
- Monoclonal antibodies to Pasteurella haemolytica serotype 1 lipopolysaccharide: demonstration of antigenic similarities among several serotypes.
- Monoclonal antibodies against rabies virus produced by somatic cell hybridization: detection of antigenic variants.
- Antigenic analysis of Japanese encephalitis virus by using monoclonal antibodies.