Detecção do vírus dengue pela técnica de aglutinação do látex modelo experimental.

AUTOR(ES)
DATA DE PUBLICAÇÃO

2007

RESUMO

Dengue is the arthropod-borne transmitted viral disease of highest worldwide prevalence in mortality and morbidity. The proportion is pandemic ranging 1.6 million of infected patients yearly. Clinical presentation associated to epidemiological factors such as dengue prevalence in the patients origin have been the only mean for early diagnosis. Laboratorial diagnosis, the conclusive, requires several days when there is viral isolation. Serological methods depend on high level of specific antibodies, and molecular methods are not available for the majority of laboratories of diagnosis and routine. The purpose of this study was to develop an agglutination method using latex to detect dengue virus, using biological samples of mice infected with dengue 1 Mochizuki strain by intracerebral via, and anti-dengue 1 specific antibodies from immunized mice. According to the results, this method was feasible for the dengue viruses diagnosis in positive samples of experimental animals. It provides further approaches for rapid detection of dengue in susceptible populations during the first days of the disease.

ASSUNTO(S)

virologia latex fixation tests dengue virus diagnostico precoz anatomia patologica e patologia clinica vírus da dengue pruebas de fijac?on de latex dengue viruses early diagnosis latex agglutination viroly testes de fixação da látex diagnóstico precoce

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