Detection of a Gene Cluster That Is Dispensable for Human Herpesvirus 6 Replication and Latency

AUTOR(ES)

Kondo, Kazuhiro

FONTE

American Society for Microbiology

RESUMO

The U3-U7 gene cluster of human herpesvirus 6 (HHV-6) was replaced with an enhanced green fluorescent protein-puromycin gene cassette containing the cytomegalovirus major immediate-early promoter. Neither viral replication in T cells nor latency and reactivation in macrophages was impaired. During HHV-6 latency, the cytomegalovirus promoter used the transcription start sites employed in cytomegalovirus latency.

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