Development and validation of UV spectrophotometric method for determination of levofloxacin in pharmaceutical dosage forms
AUTOR(ES)
Kassab, Nájla Mohamad, Amaral, Marcos Serrou do, Singh, Anil Kumar, Santoro, Maria Inês Rocha Miritello
FONTE
Química Nova
DATA DE PUBLICAÇÃO
2010
RESUMO
The objective of this research was to develop and validate an alternative analytical method for quantitative determination of levofloxacin in tablets and injection preparations. The calibration curves were linear over a concentration range from 3.0 to 8.0 μg mL-1. The relative standard deviation was below 1.0% for both formulations and average recovery was 101.42 ± 0.45% and 100.34 ± 0.85% for tablets and injection formulations, respectively. The limit of detection and limit of quantitation were 0.08 and 0.25 μg mL-1, respectively. It was concluded that the developed method is suitable for the quality control of levofloxacin in pharmaceuticals formulations.
Documentos Relacionados
- RP-HPLC method development and validation for estimation of rivaroxaban in pharmaceutical dosage forms
- Spectrophotometric and HPLC determination of deflazacort in pharmaceutical dosage forms
- Development and validation of an UV spectrophotometric method for the determination of aliskiren in tablets
- Development and validation of an UV-derivative spectrophotometric method for determination of glimepiride in tablets
- Development and validation of spectrophotometric method for the determination of DPP-4 inhibitor, sitagliptin, in its pharmaceutical preparations