Development of leukemia in mice transgenic for the tax gene of human T-cell leukemia virus type I.

AUTOR(ES)

Grossman, W J

RESUMO

The human T-cell leukemia virus type I Tax protein trans-activates several cellular genes implicated in T-cell replication and activation. To investigate its leukemogenic potential, Tax was targeted to the mature T-lymphocyte compartment in transgenic mice by using the human granzyme B promoter. These mice developed large granular lymphocytic leukemia, demonstrating that expression of Tax in the lymphocyte compartment is sufficient for the development of leukemia. Furthermore, these observations suggest that human T-cell leukemia virus infection may be involved in the development of large granular lymphocytic leukemia.

Documentos Relacionados

• Transgenic thymocytes are refractory to transformation by the human T-cell leukemia virus type I tax gene.
• Adult T-cell leukemia/lymphoma not associated with human T-cell leukemia virus type I.
• Oncogenic transformation by the tax gene of human T-cell leukemia virus type I in vitro.
• Thymic atrophy characteristic in transgenic mice that harbor pX genes of human T-cell leukemia virus type I.
• Overexpression of transforming growth factor-beta in transgenic mice carrying the human T-cell lymphotropic virus type I tax gene.