Developmental regulation of transcription by a tissue-specific TAF homolog
AUTOR(ES)
Hiller, Mark A.
FONTE
Cold Spring Harbor Laboratory Press
RESUMO
Alternate forms of the general transcription machinery have been described in several tissues or cell types. However, the role of tissue-specific TBP-associated factors (TAFIIs) and other tissue-specific transcription components in regulating differential gene expression during development was not clear. Here we show that the cannonball gene of Drosophila encodes a cell type-specific homolog of a more ubiquitously expressed component of the general transcription factor TFIID. cannonball is required in vivo for high level transcription of a set of stage- and tissue-specific target genes during male gametogenesis. Regulation of transcription by cannonball is absolutely required for spermatogenesis, as null mutations block meiotic cell cycle progression and result in a complete failure of spermatid differentiation. Our results demonstrate that cell type-specific TAFIIs play an important role in developmental regulation of gene expression.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=312677Documentos Relacionados
- Developmental and tissue-specific regulation of mouse telomerase and telomere length.
- Tissue-specific expression and developmental regulation of the rat apolipoprotein B gene.
- Tissue-specific expression and developmental regulation of the human fgr proto-oncogene.
- Developmental and tissue-specific regulation of the Q10 class I gene by DNA methylation.
- Tissue-specific overexpression of lipoprotein lipase causes tissue-specific insulin resistance
