Different population dynamics of human T cell lymphotropic virus type II in intravenous drug users compared with endemically infected tribes
AUTOR(ES)
Salemi, Marco
FONTE
The National Academy of Sciences
RESUMO
The phylogeny of human T cell lymphotropic virus type II (HTLV-II) was investigated by using strains isolated from Amerindian and Pygmy tribes, in which the virus is maintained primarily through mother-to-child transmission via breast-feeding, and strains from intravenous drug users (IDUs), in which spread is mainly blood-borne via needle sharing. Molecular clock analysis showed that HTLV-II has two different evolutionary rates with the molecular clock for the virus in IDUs ticking 150–350 times faster than the one in endemically infected tribes: 2.7 × 10−4 compared with 1.71/7.31 × 10−7 nucleotide substitutions per site per year in the long terminal repeat region. This dramatic acceleration of the evolutionary rate seems to be related with the mode of transmission. Mathematical models showed the correlation of these two molecular clocks with an endemic spread of HTLV-II in infected tribes compared with the epidemic spread in IDUs. We also noted a sharp increase in the population size of the virus among IDUs during the last decades probably caused by the worldwide increase in intravenous drug use.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=23934Documentos Relacionados
- Cytokine production by endothelial cells infected with human T cell lymphotropic virus type I.
- Predictors of survival in human immunodeficiency virus type 1-seropositive intravenous drug users.
- Human T-Lymphocyte Transformation with Human T-Cell Lymphotropic Virus Type 2
- Factors associated with pain in individuals infected by human T-cell lymphotropic virus type 1 (HTLV-1)
- Prevalence of Bowel Symptoms in Patients Infected with Human T-Lymphotropic type 1 Virus
