Differential processing of RNA transcribed from the single-copy Drosophila myosin heavy chain gene produces four mRNAs that encode two polypeptides.
AUTOR(ES)
Rozek, C E
RESUMO
We report the sequence of genomic DNA at the 3' end of the single-copy Drosophila myosin heavy chain (MHC) gene and the structure and sequence at the 3' end of four MHC mRNAs. Two mRNAs, 7.2-kilobases (kb) and 8.0 kb in length, are expressed in all stages of development in which detectable levels of muscle-specific mRNAs accumulate. These mRNAs differ by alternate choice of two poly(A) sites within the same exon. Sequence information predicts that these two mRNAs can encode one MHC polypeptide. Two additional MHC mRNAs, 8.0 kb and 8.6 kb in length, are expressed only in late pupal and adult stages of development. These two stage-specific MHC mRNAs use the same poly(A) sites as the MHC mRNAs described above but have a different splicing pattern and thus include an additional exon. Sequence information predicts that these two stage-specific MHC mRNAs encode a second MHC polypeptide with a different COOH terminus.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=323244Documentos Relacionados
- Different 3'-end processing produces two independently regulated mRNAs from a single H1 histone gene.
- Evidence that populations of Dictyostelium single-copy mRNA transcripts carry common repeat sequences.
- Distinct single-copy sequence sets in sea urchin nuclear RNAs.
- Characterization of the chicken vimentin gene: Single copy gene producing multiple mRNAs
- Identification of chorion protein precursors and the mRNAs that encode them in Drosophila melanogaster.