Differential regulation of the two genes encoding Saccharomyces cerevisiae cytochrome c oxidase subunit V by heme and the HAP2 and REO1 genes.
AUTOR(ES)
Trueblood, C E
RESUMO
In Saccharomyces cerevisiae, the COX5a and COX5b genes encode two forms of cytochrome c oxidase subunit V, Va and Vb. We report here that heme increases COX5a expression and decreases COX5b expression and that the HAP2 and REO1 genes are involved in positive regulation of COX5a and negative regulation of COX5b, respectively. Heme regulation of COX5a and COX5b may dictate which subunit V isoform is available for assembly into cytochrome c oxidase under conditions of high- and low-oxygen tension.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=365531Documentos Relacionados
- Structural analysis of two genes encoding divergent forms of yeast cytochrome c oxidase subunit V.
- Regulation of the yeast CYT1 gene encoding cytochrome c1 by HAP1 and HAP2/3/4.
- Nucleotide sequence of the gene encoding cytochrome c oxidase subunit VII from Saccharomyces cerevisiae.
- Cloning and molecular analysis of the HAP2 locus: a global regulator of respiratory genes in Saccharomyces cerevisiae.
- Sequence and nuclear localization of the Saccharomyces cerevisiae HAP2 protein, a transcriptional activator.