Dimorfismo alélico na proteína de superfície MSP-6 de merozoítos de Plasmodium falciparum. / Allelic dimorphism in Plasmodium falciparum merozoite surface protein-6 (MSP-6).
AUTOR(ES)
Rogério Lauria da Silva
DATA DE PUBLICAÇÃO
2008
RESUMO
The development of a vaccine against malaria caused by Plasmodium falciparum has been hampered by the high level of antigen polymorphism exhibited by this parasite. Allelic dimorphism is a pattern in which every observed allele of a gene is clearly grouped into one of two families. The dimorphic protein MSP-6 forms a complex with MSP-1 (also dimorphic) on merozoite surface. The msp-6 genes were sequenced in isolates obtained from 21 patients from Brazil, plus 2 isolates from Tanzania, Africa, to study nucleotide diversity and geographic distribution of alleles. Both families are globally distributed. Moreover, no association was observed between the MSP-1 and MSP-6 allelic types. Orthologous gene of msp-6 in P. reichenowi, chimpanzee parasite and sister group of P. falciparum, was sequenced for evolutionary studies. Dimorphic alleles of MSP-6 seem to have originated from an ancestral polymorphic population and are maintained by balancing selection. The high degree of conservation observed within each allelic family makes MSP-6 an promising target for vaccine development.
ASSUNTO(S)
membrane protein msp-6 dimorfismo alélico proteínas da membrana malaria allelic dimorphism plasmodium falciparum malária msp-6 plasmodium falciparum
Documentos Relacionados
- Roles of conserved and allelic regions of the major merozoite surface protein (gp195) in immunity against Plasmodium falciparum.
- Plasmodium falciparum Merozoite Surface Protein 6 Is a Dimorphic Antigen
- Merozoite surface protein sequence from the Camp strain of the human malaria parasite Plasmodium falciparum.
- Genetic relatedness of Plasmodium falciparum isolates and the origin of allelic diversity at the merozoite surface protein-1 (MSP-1) locus in Brazil and Vietnam
- Third form of the precursor to the major merozoite surface antigens of Plasmodium falciparum.