Direct homocysteine biosynthesis from O-succinylhomoserine in Escherichia coli: an alternate pathway that bypasses cystathionine.
AUTOR(ES)
Simon, M
RESUMO
Mutations were found which enable Escherichia coli K-12 to form homocysteine in the absence of cystathionase. The formation of homocysteine in the mutant strains required cystathionine gamma-synthetase, the metB gene product, but bypassed the normal intermediate cystathionine. It is concluded that cystathionine gamma-synthetase catalyzes the formation of homocysteine directly from O-succinylhomoserine and an as-yet-unidentified sulfur donor. The mutation apparently causes the formation of this sulfur donor and has been named metQ. The expression of the metQ gene is under catabolite repression.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=217410Documentos Relacionados
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