Direct Measurement of the Anti-Influenza Agent Zanamivir in the Respiratory Tract following Inhalation

AUTOR(ES)

Peng, Amy W.

FONTE

American Society for Microbiology

RESUMO

In a single-center, randomized study, zanamivir (Relenza) concentrations in induced sputum samples and nasal washings of healthy adults following oral inhalation were measured. Concentrations in sputum exceeded the median viral neuraminidase 50% inhibitory concentration at 6, 12, and 24 h, and those in nasal washings did so at 6 and 12 h. There were no zanamivir-related adverse events or laboratory abnormalities.

Documentos Relacionados

• The Anti-Influenza Virus Agent 4-GU-DANA (Zanamivir) Inhibits Cell Fusion Mediated by Human Parainfluenza Virus and Influenza Virus HA
• Comparison of the Anti-Influenza Virus Activity of RWJ-270201 with Those of Oseltamivir and Zanamivir
• Enhancement of anti-influenza A virus cytotoxicity following influenza A virus vaccination in older, chronically ill adults.
• Mechanism of Action of Anti-Influenza Benzamidine Derivatives
• The Anti-Influenza Virus Drug Rimantadine Has Trypanocidal Activity