Distinct forms of both alpha and beta subunits are present in the human Ia molecular pool.
AUTOR(ES)
Accolla, R S
RESUMO
Two distinct subsets of human Ia molecules, called NG1 and NG2, present in all individuals irrespective of their HLA-DR phenotype, which were previously defined by their reactivity with two monoclonal hybridoma antibodies, D1--12 and D4--22, were analyzed by two-dimensional peptide mapping techniques. Results show that, in the Ia molecular pool from a single individual, small beta subunits of the NG1 and NG2 subsets display significant differences from each other. In addition, beta subunits of the same subset from two different allotype Ia molecular pools are also different from each other, thus indicating that NG1 and NG2 subsets carry polymorphic specificities. Moreover, large alpha chains of NG1 and NG2 subsets are different from each other; however, no significant differences are observed in alpha chains of the same subset when different allotype Ia pools are analyzed. The possible genetic implications of these findings are discussed.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=319829Documentos Relacionados
- Both alpha and beta subunits of human choriogonadotropin photoaffinity label the hormone receptor.
- G protein diversity: a distinct class of alpha subunits is present in vertebrates and invertebrates.
- Both sodium channel II and IIA alpha subunits are expressed in rat brain.
- A and B forms of the androgen receptor are present in human genital skin fibroblasts.
- Sequence of human haptoglobin cDNA: evidence that the alpha and beta subunits are coded by the same mRNA.