Distinct Response Kinetics of Gamma Interferon and Interleukin-4 in Bovine Tuberculosis

AUTOR(ES)

Rhodes, S. G.

FONTE

American Society for Microbiology

RESUMO

This study shows that gamma interferon (IFN-γ) and interleukin-4 (IL-4) cytokine responses are produced by peripheral blood cells in cattle infected with Mycobacterium bovis. The different kinetics of the IFN-γ and IL-4 responses to bovine tuberculin and to ESAT-6 following experimental intratracheal infection with M. bovis are described. An early increase in IFN-γ was observed that was maintained throughout the period studied. In contrast, the IL-4 response was delayed and confined to a peak of activity lasting 6 to 8 weeks. Interestingly, an experimental challenge of cattle with a lower dose of M. bovis which did not result in the development of lesions, positive DTH skin test, or substantial IFN-γ responses nevertheless generated strong specific IL-4 responses. Investigation of naturally infected M. bovis field reactors showed increased IFN-γ and IL-4 responses compared to uninfected cattle and that both of these cytokines were equally able to differentiate infected from uninfected animals. The magnitude of the M. bovis-induced IL-4 responses were found to be similar to the antigen-specific IL-4 responses of cattle infected with the parasitic nematode Onchocerca ochengi, further supporting the presence of this type 2 cytokine in bovine tuberculosis.

Documentos Relacionados

• Roles of interferon-gamma and interleukin-4 in murine lupus.
• Experimental Lyme Arthritis in the Absence of Interleukin-4 or Gamma Interferon
• Roles of gamma interferon and interleukin-4 in genetically determined resistance to Coccidioides immitis.
• Reciprocal Immunomodulatory Effects of Gamma Interferon and Interleukin-4 on Filaria-Induced Airway Hyperresponsiveness
• Interferon‐gamma and interleukin‐4 gene polymorphisms in Caucasian idiopathic inflammatory myopathy patients in UK