Distribuição dos receptores de acetilcolina e terminais nervosos na junção neuromuscular de fibras musculares regeneradas
AUTOR(ES)
Zarif Torres Rehder Mendes
DATA DE PUBLICAÇÃO
2004
RESUMO
Mdx mice have deficiency of dystrophin and cycles of muscle fiber regeneration. Changes in the distribution of acetylcholine receptors have been reported at the neuromuscular junction of mdx and may be a consequence of muscle fiber regeneration. At the present, we verified whether the distribution of receptors is still altered in long-term regenerated muscle fibers from C57Bl/10 mice. The left sternomastoid muscle of adult mice was injected with 60 µl of lidocaine hydrochloride to induce degeneration-regeneration. Some animals had the STN denervated at the time of lidocaine injection. After 90 and 150 days, receptors were labeled with rhodamine-bungarotoxin for confocal observation. For both periods studied, receptors were distributed into clusters. In denervated-regenerated fibers, receptors were distributed as branches, similar to normal denervated muscles. This suggests that nerve-dependent mechanisms are involved in the changes in receptor distribution seen in regenerated muscle fibers, after lidocaine treatment and a similar phenomenon might explain the changes in receptor distribution seen in dystrophic muscle fibers.
ASSUNTO(S)
acetylcholine receptors neuromuscular junction muscle fiber regeneration nerve terminal musculos sistema nervoso mdx mice acetilcolina
ACESSO AO ARTIGO
http://libdigi.unicamp.br/document/?code=vtls000324095Documentos Relacionados
- Distribuição dos receptores de acetilcolina e da oxido nitrico sintase neuronal na junção neuromuscular de fibras musculares regeneradas
- O oxido nitrico na plasticidade das celulas de Schwann terminais e dos terminais nervosos da junção neuromuscular
- Distribuição dos receptores de acetilcolina e eliminação sinaptica durante o desenvolvimento da junção neuromuscular do camundongo MDX
- Influencia da inervação na distribuição dos receptores de acetilcolina na junção neuromuscular distrofica
- Influencia da membrana basal juncional na redistribuição topografica das junções neuromusculares em fibras musculares regeneradas