DNA Methylation in Lysogens of Pathogenic Burkholderia spp. Requires Prophage Induction and Is Restricted to Excised Phage DNA

AUTOR(ES)

Smith, M. J.

FONTE

American Society for Microbiology

RESUMO

Burkholderia mallei-specific phage ΦE125 encodes DNA methyltransferases in both the lysogenic and replication modules within its genome. Characterization of DNA methylation in recombinant systems, specifically in ΦE125 lysogenic strains of B. mallei and Burkholderia thailandensis, revealed that, upon induction, cytosine methylation was targeted specifically to the phage episome but not the phage provirus or the host chromosome.

Documentos Relacionados

• In Vitro Susceptibilities of Burkholderia mallei in Comparison to Those of Other Pathogenic Burkholderia spp.
• Induction of prophage SPO2 in Bacillus subtilis: isolation of excised prophage DNA as a covently closed circle.
• GlbN (cyanoglobin) is a peripheral membrane protein that is restricted to certain Nostoc spp.
• Molecular biology of the symbiotic-pathogenic bacteria Xenorhabdus spp. and Photorhabdus spp.
• Developmental regulation of CUP gene expression through DNA methylation in Mucor spp.