Dopamine responsiveness is regulated by targeted sorting of D2 receptors
AUTOR(ES)
Bartlett, Selena E.
FONTE
National Academy of Sciences
RESUMO
Aberrant dopaminergic signaling is a critical determinant in multiple psychiatric disorders, and in many disease states, dopamine receptor number is altered. Here we identify a molecular mechanism that selectively targets D2 receptors for degradation after their activation by dopamine. The degradative fate of D2 receptors is determined by an interaction with G protein coupled receptor-associated sorting protein (GASP). As a consequence of this GASP interaction, D2 responses in rat brain fail to resensitize after agonist treatment. Disruption of the D2-GASP interaction facilitates recovery of D2 responses, suggesting that modulation of the D2-GASP interaction is important for the functional down-regulation of D2 receptors.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1183554Documentos Relacionados
- Schizophrenia: More dopamine, more D2 receptors
- Increased baseline occupancy of D2 receptors by dopamine in schizophrenia
- Transcription mediated by a cAMP-responsive promoter element is reduced upon activation of dopamine D2 receptors.
- Striatal dopamine D2 receptors in tardive dyskinesia: PET study.
- Link between D1 and D2 dopamine receptors is reduced in schizophrenia and Huntington diseased brain.