Dribble, the Drosophila KRR1p Homologue, Is Involved in rRNA Processing

AUTOR(ES)

Chan, H.Y. Edwin

FONTE

The American Society for Cell Biology

RESUMO

The Drosophila dribble (dbe) gene encodes a KH domain protein, homologous to yeast KRR1p. Expression of dbe transcripts is ubiquitous during embryogenesis. Overexpressed Dribble protein is localized in the nucleus and in some cell types in a subregion of the nucleolus. Homozygous dbe mutants die at first instar larval stage. Clonal analyses suggest that dbe+ is required for survival of dividing cells. In dbe mutants, a novel rRNA-processing defect is found and accumulation of an abnormal rRNA precursor is detected.

Documentos Relacionados

• Rok1p is a putative RNA helicase required for rRNA processing.
• Cloning of a gene involved in rRNA precursor processing and 23S rRNA cleavage in Rhodobacter capsulatus.
• Human RanGTPase-activating protein RanGAP1 is a homologue of yeast Rna1p involved in mRNA processing and transport.
• Hdf1, a yeast Ku-protein homologue, is involved in illegitimate recombination, but not in homologous recombination.
• Suppression of yeast RNA polymerase III mutations by FHL1, a gene coding for a fork head protein involved in rRNA processing.