Dysplasia and adenocarcinoma of the Barrett s esophagus secondadry to the duodenogastroesophagic reflux and sodium nitrite : experimental study in rats / Displasia e adenocarcinoma no esofago de Barrett secundarios ao refluxo duodeno-esofago-gastrico e nitrito de sodio : estudo experimental em ratos

AUTOR(ES)
DATA DE PUBLICAÇÃO

2009

RESUMO

The nitrates and nitrites are salts has been using a lot as conservants and chemical additives of foods, that in this current context of accentuated increase of the world population and shortage of foods, they will be used more. On the other hand, the profile of the society is more and more to use industrialized foods ready for consumption, which they utilize several conservants in its elaboration. These salts have harmful action to the organism in specific situations, as demonstrated in many experiments. The gastroesophageal reflux disease has been growing in incidence all over the world mainly in the United States and Europe and related to the alarming indexes of growth of the frequency of carcinomas of the esophagogastric junction. The objective of this research was to analyze the experimental model of duodenum-gastro- esophagic reflux and the ingestion of a solution of sodium nitrite in the genesis of the adenocarcinoma associated to the Barrett s esophagus. Sixty Wistar male rats were divided in four groups: twenty animals controls not operated (10 animals ingested only water and 10 animals ingested water plus sodium nitrite) and forty animals submitted to the side-to-side duodenum-gastro-esophagic anastomosis (20 animals ingested only water and 20 animals ingested water plus solution of sodium nitrite). The Vienna Classification for dysplasia and adenocarcinoma was used in the analysis of the results. After 42 weeks of observation, in the group operated without nitrite ingestion the Barrett s esophagus was found in 26,3% (5/19) of the animals, while in the group operated associate to the nitrite ingestion, it was found in 72,3% (13/18) of the animals, and in this last group it was also found six adenocarcinomas (33,3%). Any animal no operated presented Barrett s esophagus. The categories 2, 3 and 5 of the Vienna Classification were only found in the animals operated that they ingested sodium nitrite (66,7%). The final conclusion is that the ingestion of sodium nitrite associated to duodenum-gastro-esophagic reflux has important participation in the genesis of the adenocarcinoma associated to the Barrett s esophagus

ASSUNTO(S)

esophagus esofago de barrett nitritos nitrites barrett esophagus esofago

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