Early Signs of Lead-exposure: A comparative study of laboratory tests
AUTOR(ES)
Bruin, A. de
RESUMO
Previous work has shown that urinary lead, coproporphyrin (CP), and δ-aminolaevulinic acid (ALA) are closely related after exposure to lead. We have confirmed the relationship in 50 automobile workers with different exposures, and have also estimated porphobilinogen (PBG) levels. There was some evidence that a raised ALA level gave an earlier sign of lead absorption than a raised CP level. ALA-dehydratase activity (converting ALA to PBG) was greatly reduced by exposure, on the average to 20% of normal. This reduction in activity was strongly correlated with the increases in urinary lead, CP, and ALA and is the most sensitive test of exposure to lead.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1008582Documentos Relacionados
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