Ectopic recombination between Ty elements in Saccharomyces cerevisiae is not induced by DNA damage.
AUTOR(ES)
Parket, A
RESUMO
Mitotic recombination is increased when cells are treated with a variety of physical and chemical agents that cause damage to their DNA. We show here, using Saccharomyces cerevisiae strains that carry marked Ty elements, that recombination between members of this family of retrotransposons is not increased by UV irradiation or by treatment with the radiomimetic drug methyl methanesulfonate. Both ectopic recombination and mutation events were elevated by these agents for non-Ty sequences in the same strain. We discuss possible mechanisms that can prevent the induction of recombination between Ty elements.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=360368Documentos Relacionados
- Involvement of cDNA in homologous recombination between Ty elements in Saccharomyces cerevisiae.
- Allelic and Ectopic Recombination between Ty Elements in Yeast
- Specific transcripts are elevated in Saccharomyces cerevisiae in response to DNA damage.
- Saccharomyces cerevisiae SPT3 gene is required for transposition and transpositional recombination of chromosomal Ty elements.
- Promoter elements of the PHR1 gene of Saccharomyces cerevisiae and their roles in the response to DNA damage.