Efeito da ação tópica do colírio de fenilefrina a 10% no posicionamento palpebral de indivíduos normais e portadores de blefaroptose adquirida involucional / Effect of 10% phenylephrine eye drops action in the eyelid position in healthy subjects and in patients with acquired involutional blepharoptosis

AUTOR(ES)

Tânia Pereira Nunes

DATA DE PUBLICAÇÃO

2008

RESUMO

INTRODUCTION: There are few studies in the literature on the effect of drugs on the vertical positioning of the eyelids. This issue is important in the analysis of the eyelid dynamics mainly in disorders such as blepharoptosis. The aim of this study is to determine the action of a single drop of 10% phenylephrine on the upper and lower eyelids of healthy subjects and patients with acquired involutional blepharoptosis and observe the occurrence of changes in the positioning of the upper and lower eyelids of the contralateral eye. METHOD: A prospective clinical trial was done with healthy subjects and patients with acquired involutional blepharoptosis. The patients were submitted to the instillation of a single drop of 10% phenylephrine in one eye. All subjects were filmed before and after instillation of medication (3, 10, 15, 30, 45 and 60 minutes). The images were submitted to digital processing and edited to analyze lid measurements. A horizontal line was drawn from the medial canthus toward the outer. The upper eyelid height was measured as the distance between the highest point of the upper eyelid margin and the horizontal line drawn. The lower eyelid height was the distance between the lowest point of the margin lower eyelid and the drawn line. RESULTS: Seventy healthy subjects and 40 patients with acquired involutional blepharoptosis were included. Most patients had bilateral (92,5%) and mild blepharoptosis (45%). After 10% phenylephrine instillation, upper lid height showed a mean elevation of 0,92 mm, which was significantly different at all time measurements (p<0,001). The lower eyelid height changed with a mean retraction of 0,40 mm. In the contralateral eye was observed a fall of upper eyelid in all most all times studied, with the lowest level observed at 3 minutes (with average fall of 0,66 mm). The contralateral lower eyelid showed an average elevation of 0,35 mm. CONCLUSION: Instillation of a single drop of 10% phenylephrine altered the position of upper and lower eyelids on the tested eye, as well as of the contralateral eye on both groups, healthy subjects and patients with acquired involutional blepharoptosis

ASSUNTO(S)

blepharoptosis diagnostic imaging phenylephrine/administration &dosage diagnóstico por imagem fenilefrina/administração &dosagem eyelids blefaroptose pálpebras

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