Efeitos da administração prolongada do esteróide anabolizante decanoato de nandrolona em comportamentos emocionais e na expressão de genes relacionados ao sistema serotoninérgico em diferentes áreas cerebrais de camundongos / Effects of prolonged administration of the anabolic-androgenic steroid nandrolone decanoate in emotional behaviors and serotonergic system related genes expression in several brain areas of mice

AUTOR(ES)

Guilherme Ambar

DATA DE PUBLICAÇÃO

2008

RESUMO

Nandrolone decanoate is a highly abused anabolic-androgenic steroid (AAS) by individuals looking for gains in physical strength or body appearance. Supraphysiological doses of this testosterone synthetic derivative have been associated with many physical and psychiatric adverse effects, especially reported episodes of impulsiveness and overt aggressive behavior. Since the neural mechanisms underlying AAS-induced behavioral disinhibition are unknown, we investigated the integrity of serotonergic system transcription in several brain areas of mice under prolonged nandrolone administration. Male C57Bl/6J mice received 15 mg/kg of nandrolone decanoate subcutaneously once daily for 28 days, and different sets of animals were used to investigate motor and emotion-related behaviors or 5-HT-related gene expression by qRT-PCR. AAS-injected mice had increased body weight, were hyperactive and displayed more anxious-like behaviors in novel environments. They exhibited reduced immobility in the forced swim test, higher probability of being aggressive and elevated impulsivity to attack the opponent. AAS induced substantial reduction in the transcription of most postsynaptic 5-HT receptors investigated in the amygdala and prefrontal cortex. Interestingly, 5-HT1B mRNA was further reduced in the hippocampus and hypothalamus. At the midbrain level, there was no alteration in 5- HT receptors, transporter or synthetic enzyme gene transcription. In conclusion, high doses of AAS nandrolone in male mice recapitulate the behavioral disinhibition observed in abusers. Furthermore, they are associated with overall decrease in 5-HT receptor gene expression in the amygdala and prefrontal cortex, implicating these areas as critical sites for AASinduced effects and indicating a role for the 5-HT1B receptor in this behavioral disinhibition

ASSUNTO(S)

expressão gênica decanoato de nandrolona aggression serotonergic system sistema serotoninérgico agressividade nandrolone decanoate gene expression

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