Effect of 2-Deoxyglucose on Schizosaccharomyces pombe
AUTOR(ES)
Megnet, Roland
RESUMO
Megnet, Roland (Institut für Allgemeine Mikrobiologie der Universität, Bern, Switzerland). Effect of 2-deoxyglucose on Schizosaccharomyces pombe. J. Bacteriol. 90:1032–1035. 1965.—Cultivation of Schizosaccaromyces pombe in a medium containing 2-deoxyglucose (100 μg/ml) results in the death of the cells after an initial period of apparently normal growth. At higher deoxyglucose concentration (400 μg/ml), the cells die immediately after inoculation. Only growing cells are killed, and microscopic inspection of the cultures reveals cell-wall fragments of lysed cells. A mutant resistant to 2-deoxyglucose, which cannot use glucose as a carbon source, was found to be partially deficient in hexokinase. The data constitute evidence for the inhibition of some reaction(s) in the synthesis of cell-wall polysaccharides by metabolites of 2-deoxyglucose in this organism.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=315772Documentos Relacionados
- Effect of 2-Deoxyglucose on Cell Wall Formation in Saccharomyces cerevisiae and Its Relation to Cell Growth Inhibition
- Studies on the Diversity of Inositol-Containing Yeast Phospholipids: Incorporation of 2-Deoxyglucose into Lipid
- Uptake of the glucose analogue 2-deoxyglucose by germinating mitospores of Allomyces macrogynus.
- Single-unit and 2-deoxyglucose studies of side inhibition in macaque striate cortex.
- Saccharomyces cerevisiae acquires resistance to 2-deoxyglucose at a very high frequency.
