Effect of a synthetic pyrethroid deltamethrin on excitability changes following a nerve impulse.

AUTOR(ES)

Parkin, P J

RESUMO

Excitability changes following a nerve impulse were studied in the rat tail. Supernormal nerve excitability in control animals was present, as in other vertebrate nerve fibres, from 4-30 ms and was followed by a period of subnormal excitability extending up to 100-200 ms. Two to seven hours after intravenous administration of 1.5 mg/kg deltamethrin, supernormality was increased in degree and prolonged in duration for up to 400 ms. A minor effect was still detectable 24 hours after injection. This effect of deltamethrin on nerve excitability is probably due to persistent slight depolarisation of the nerve membrane resulting from its known effect of maintaining a proportion of sodium channels open for up to several hundred milliseconds following a nerve impulse.

Documentos Relacionados

• Momentary alteration of the postsynaptic membrane during transmission of a single nerve impulse.
• The effects of the pyrethroids deltamethrin and cismethrin on nerve excitability in rats.
• Brief occurrence of a population of presynaptic intramembrane particles coincides with transmission of a nerve impulse.
• The effect of ischaemia on the excitability of human sensory nerve.
• CONSIDERATIONS ON THE NERVE IMPULSE MECHANISM*