Effect of acute and chronic beta-blockade on carbon dioxide sensitivity in normal man.
AUTOR(ES)
Hutchinson, P F
RESUMO
The effect of beta-adrenoceptor antagonists on the respiratory response to carbon dioxide rebreathing was studied in eight normal subjects. Propranolol, atenolol, metoprolol, and placebo were given in random, double-blind fashion. Subjects were studied before each treatment period, after one dose, and after eight days of treatment with each drug. A rebreathing method was used to produce progressive hypercapnia and the respiratory response was assessed by measuring minute ventilation and maximum rate of change of inspiratory mouth pressure. Beta-blockade was assessed by the reduction in heart rate during steady state exercise on a cycle ergometer. There was no change in the respiratory response to carbon dioxide after a single dose or eight days treatment of any drug. All three active drugs produced a significant reduction in exercise heart rate. The forced expiratory volume in one second was not altered by any of the drugs.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=471401Documentos Relacionados
- The effect of beta-blockade on myocardial remodelling in Chagas' cardiomyopathy
- Effects of chronic beta-blockade on intra-arterial blood pressure during motor car driving.
- Effects of acute and chronic beta-receptor blockade on ventricular repolarisation in man.
- Beneficial effects of long-term beta-blockade in congestive cardiomyopathy.
- Adverse effects of beta-blockade withdrawal in patients with congestive cardiomyopathy.