Effect of Cyclopentaneglycine on Metabolism in Salmonella typhimurium
AUTOR(ES)
O'neill, J. Patrick
RESUMO
Cyclopentaneglycine (CPG) inhibited the growth of wild-type Salmonella typhimurium. The inhibition was overcome by isoleucine or any isoleucine precursor formed after threonine. CPG appeared to mimic isoleucine as a strong inhibitor of the activity of l-threonine deaminase. The analogue was a poor inhibitor of isoleucyl-transfer ribonucleic acid synthetase. CPG did not appear to be incorporated into protein nor did it replace isoleucine in repression. Cells that had recovered from growth inhibition by CPG had derepressed levels of the isoleucine-valine biosynthetic enzymes.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=251312Documentos Relacionados
- Effect of the Proline Analogue Baikiain on Proline Metabolism in Salmonella typhimurium
- Effect of 4-Azaleucine upon Leucine Metabolism in Salmonella typhimurium1
- Effect of volatile fatty acids on Salmonella typhimurium.
- Effects of crp mutations on adenosine 3',5'-monophosphate metabolism in Salmonella typhimurium.
- Correlation of Succinate Metabolism and Virulence in Salmonella typhimurium
